Abstract
We recently reported the intraspecies transmission of L-type atypical bovine spongiform encephalopathy (BSE). To clarify the peripheral pathogenesis of L-type BSE, we studied prion distribution in nerve and lymphoid tissues obtained from experimentally challenged cattle. As with classical BSE prions, L-type BSE prions accumulated in central and peripheral nerve tissues.
Highlights
We recently reported the intraspecies transmission of L-type atypical bovine spongiform encephalopathy (BSE)
Contrary to what we found in nerve tissues, we detected no PrPres from tests performed on lymphoid tissues obtained from any of the 5 cattle studied
We report accumulation of L-type atypical BSE prions in peripheral nerve tissues sampled from intracerebrally challenged cattle
Summary
We recently reported the intraspecies transmission of L-type atypical bovine spongiform encephalopathy (BSE). Onoe); and National Institute of Infectious Diseases, Tokyo, Japan The L-type BSE prion is much more virulent in primates and in humanized mice than is the classical BSE prion, which suggests the possibility of zoonotic risk associated with the L-type BSE prion These findings emphasize the critical importance of understanding tissue distribution of L-type BSE prions in cattle because, among the current administrative measures for BSE controls, the specified risk materials removal policy plays a crucial role in consumer protection. We report the peripheral distribution of L-type BSE prions in experimentally challenged cattle
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