Abstract
The effect of aging on the active transport of amino acid and peptide in the choroid plexus was investigated in Fischer 344 rats. The choroid plexus of lateral ventricles of the brain were incubated in buffer solution containing α-amino isobutyric acid (AIB), methionine-enkephalinamide (Met) or Tyr-D-Ala-Gly (TAG). The choroid plexus of aging rats (24 to 26 months) accumulated less AIB (at 1 mM) and TAG (at 0.06 or 1 mM) but accumulated more Met (at 0.01 or 1.5 μM) than that of the young rat (4 to 6 months). These results suggest that the effect of aging on transport activity in the choroid plexus is complex.
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