Abstract
Polyene-resistant mutants of Candida albicans accumulating 14-methyl sterols in place of ergosterol and defective in hyphal growth were isolated after ultraviolet mutagenesis. Analysis of revertants showed that the alteration in sterol composition, the inability to grow as hyphae, and the antibiotic resistance had returned to normal simultaneously. In addition, clotrimazole, which caused accumulation of 14-methyl sterols at a subfungistatic concentration, also inhibited hyphal formation but had little effect on yeast propagation. It is concluded that there is an intrinsic rather than a fortuitous relationship between sterol composition and morphogenesis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.