Abstract
After a 4h dosing period with the mothproofing agent Eulan WA New in surrounding water, most pike tissues showed a high ratio of PADs (polychloro-2-aminodiphenyl ethers; minor components of Eulan WA (New) to PCSDs (polychloro-2-[ chloromethyl-sulphonamido] diphenyl ethers; the major component and active ingredient of Eulan WA New). Particularly high PADs to PCSDs ratios were shown throughout the dosing periods in pike liver. In a second experiment, over a shorter time course and employing purified pentachloro-2-(chloromethylsulphonamido) diphenyl ether (6-PCSD), the liver was identified as a primary site of PAD formation. Very high concentrations of PCSDs and PADs were found in the bile and also appear to accumulate in the spleen and kidney.
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