Abstract
Abstract Seeking to understand the trends in participant accrual and barriers to neuro-oncology clinical trial access, we conducted a comprehensive assessment of past and ongoing neuro-oncology trials in the United States (US). Data from the ClinicalTrial.gov registry revealed that most closed trials failed to meet their enrollment goals, with the trend worsening over time. We explored factors that may impact trial accrual and access, finding an increasing demand for participant enrollment. Investigating geographic, socioeconomic, and population factors, we found that trial-hosting infrastructure may not exist in large geographically-contiguous and sparsely-populated areas, and where existent, underserves higher-populated disadvantaged areas.
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