Abstract
This study was aimed at analyzing the diagnostic value of convolutional neural network models on account of deep learning for severe sepsis complicated with acute kidney injury and providing an effective theoretical reference for the clinical use of ultrasonic image diagnoses. 50 patients with severe sepsis complicated with acute kidney injury and 50 healthy volunteers were selected in this study. They all underwent ultrasound scans. Different deep learning convolutional neural network models dense convolutional network (DenseNet121), Google inception net (GoogLeNet), and Microsoft's residual network (ResNet) were used for training and diagnoses. Then, the diagnostic results were compared with professional image physicians' artificial diagnoses. The results showed that accuracy and sensitivity of the three deep learning algorithms were significantly higher than professional image physicians' artificial diagnoses. Besides, the error rates of the three algorithm models for severe sepsis complicated with acute kidney injury were significantly lower than professional physicians' artificial diagnoses. The areas under curves (AUCs) of the three algorithms were significantly higher than AUCs of doctors' diagnosis results. The loss function parameters of DenseNet121 and GoogLeNet were significantly lower than that of ResNet, with the statistically significant difference (P < 0.05). There was no significant difference in training time of ResNet, GoogLeNet, and DenseNet121 algorithms under deep learning, as the convergence was reached after 700 times, 700 times, and 650 times, respectively (P > 0.05). In conclusion, the value of the three algorithms on account of deep learning in the diagnoses of severe sepsis complicated with acute kidney injury was higher than professional physicians' artificial judgments and had great clinical value for the diagnoses and treatments of the disease.
Highlights
As sepsis is better understood, it is defined by scholars as a clinical syndrome in which organism’s inflammatory response is maladjusted by infection, resulting in severe damage to physiology and organ functions
Accurate diagnoses and examination are extremely important [26]. 50 patients with severe sepsis complicated with acute kidney injury and 50 healthy volunteers were selected in this study
Different deep learning convolutional neural network models DenseNet121, GoogLeNet, and residual network (ResNet) were used for training and diagnoses
Summary
As sepsis is better understood, it is defined by scholars as a clinical syndrome in which organism’s inflammatory response is maladjusted by infection, resulting in severe damage to physiology and organ functions. Sepsis has extremely high morbidity and mortality in intensive care units, and it has become the leading cause of death for critically ill patients [1]. Its pathogeneses and pathological processes are complicated and closely related to inflammation, coagulation dysfunction, and immune disorders [5,6,7]. Among them, uncontrolled inflammatory response is considered to be one of the pathogeneses of sepsis. Inflammatory responses released a large amount of proinflammatory cytokines and anti-inflammatory cytokines [8]. There is often an imbalance between proinflammatory factors and anti-inflammatory factors in sepsis patients, and the inflammatory reaction is out of control, which accelerates the development of sepsis [9,10,11]. Inflammation often interacts with coagulation dysfunction and influences the development of sepsis. The decreased expression of tissue factors cannot initiate the Computational and Mathematical Methods in Medicine
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