Abstract
Superwarfarins are anticoagulants related to warfarin, and were developed as rodenticides in response to the development of resistance to warfarin in some populations of rats. This drug class includes brodifacoum, bromadiolone, difenacoum, and flocoumafen. Over 80% of rodenticides used on British farms, and nearly all of those used in the domestic environment, contain a superwarfarin. The mode of action of the superwarfarins is similar to warfarin in that they inhibit hepatic synthesis of prothrombin and vitamin-K-dependent cofactors. These drugs have longer biological half-lives (24 days or more) and are said to be more acutely toxic to mammals than warfarin.
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