Accidental isoniazid toxicosis in a dog

Abstract

AbstractA 7‐month‐old, male, spitz dog was presented with history of accidental ingestion of isoniazid tablets. On presentation, signs of seizures, involuntary defecation and urination, vomiting and excess salivation were noticed. Clinical examination revealed tachycardia, ataxia, increased respiratory rate and severe dehydration. Therapy was aimed at stabilisation of the dog with fluid therapy, anti‐convulsants and antidote pyridoxine (at the dose rate of 60 mg/kg bodyweight). The clinical signs subsided in 4 hours of therapy. Complete blood profile revealed mild neutrophilia, hypoproteinemia, elevated blood urea nitrogen, creatinine and alkaline phosphatase. After 24 hours of therapy, apart from vomiting no other clinical signs were noticed. Fluid therapy along with anti‐emetics, proton pump inhibitors and oral pyridoxine was administered for 2 more days following first day. The dog showed complete recovery on Day 3 of therapy, and the biochemical values were back to normal on seventh day. The present case reports a dog with accidental oral ingestion of isoniazid, its clinical signs and therapeutic management.