Abstract
A subpopulation of radioresistant splenocytes (RSCs) was examined for its ability to act as accessory cells in the generation of cytotoxic thymus-dependent lymphocytes (CTLs). RSCs provided accessory functions to nylon wool-filtered spleen T cells or mature thymocytes acting as responders to allogeneic spleen T cells or mature thymocytes. The participation of Ia antigens in the accessory process was investigated using anti-Ia sera directed against the products of I-A and/or I-E/C subregions. We found that RSC accessory function was dependent upon cells expressing I-A or I-E/C antigens. Preincubation of spleen T cells with RSCs increased the ability of these cells to stimulate allogeneic spleen T cells regardless of whether RSCs were allogeneic, or semisyngeneic to the stimulator T cells.
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