Abstract
AbstractWe report our formal insertion of alkenes into benzylic C–F bonds of electron-deficient perfluoroalkylarenes under organophotocatalytic conditions with Et3N·3HF as an external fluoride source. The absence of a fluoride scavenger or other external reductant permits the formation of a carbocation and its trapping by other nucleophiles. This three-component reaction represents one of the most efficient methods for preparing a variety of complex partially fluorinated organic molecules. This redox-neutral transformation features mild conditions, a broad substrate scope, and extraordinary functional-group tolerance. Moreover, several examples of modifications of complex drug molecules further demonstrated its utility.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
