Abstract
This study was conducted to investigate epigenetic landscape across multiple species and identify transcription factors (TFs) and their roles in controlling cell fate decision events during early embryogenesis. We made a comprehensively joint-research of chromatin accessibility of five species during embryogenesis by integration of ATAC-seq and RNA-seq datasets. Regulatory roles of candidate early embryonic TFs were investigated. Widespread accessible chromatin in early embryos overlapped with putative cis-regulatory sequences. Sets of cell-fate-determining TFs were identified. YOX1, a key cell cycle regulator, were found to homologous to clusters of TFs that are involved in neuron and epidermal cell-fate determination. Our research provides an intriguing insight into evolution of cell-fate decision during early embryogenesis among organisms.
Highlights
This study was conducted to investigate epigenetic landscape across multiple species and identify transcription factors (TFs) and their roles in controlling cell fate decision events during early embryogenesis
We found many TFs match their functions of various cell fate determination by investigation of the dynamic chromatin changes and gene expression patterns of various species during different development stages
For H. sapiens, we found some TFs, PAX6, SOX2, POU3F1, HOXA10, CDX2, NANOG, TEAD4, and OCT4 were scarcely expressed across mature tissues, because they function in early stem cell development[54,55,56,57]
Summary
This study was conducted to investigate epigenetic landscape across multiple species and identify transcription factors (TFs) and their roles in controlling cell fate decision events during early embryogenesis. Embryo development of the metazoans and plants comprise a sequence of cell fate decisions in which cells are guided along a pathway of restricted potential and increasing specialisation. Root, flowers, fruits are continuously augmented to build sophisticated post-embryonic tissues This process requires coordination of cell divisions, cell fate determination, and cell communication. Starting from fertilization, embryogenesis produces the first stem cell, and by the end of embryogenesis the zygote has transformed into a mature embryo that comprises the basic tissue types identical to any post-embryonic plant[7].
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