Access to Fully Substituted Dihydropyrimidines via Dual Copper/Photoredox‐Catalyzed Domino Annulation of Oxime Esters and Imines

Abstract

AbstractA domino cyclization of oxime esters and imines has been achieved by dual photoredox/copper catalysis. A variety of structurally diverse fully substituted dihydropyrimidines have been forged in 37–88% yields at room temperature. This synthetic protocol providesN‐heterocycles with high molecular complexity and functional group diversity. The present reaction is amenable to gram‐scale synthesis, which is expected to find potential applications in organic synthesis and drug discovery. A plausible reaction mechanism is proposed.magnified image