Abstract
AbstractThe construction of quinazolines via acceptorless dehydrogenative cyclization of o‐aminobenzylamines and aldehydes in water has been accomplished. In the presence of a water‐soluble metal‐ligand bifunctional catalyst [Cp*Ir(6, 6’‐(OH)2bpy)(H2O)][OTf]2 (2 mol %), reactions were carried out at 130 °C for 12 h in water to afford the desired products in 52–83 % yields. Apparently, OH units in the bpy ligand are crucially important for the enhancement of the catalytic activity. The liberation of hydrogen gas in the process of the cyclization was also confirmed. The protocol is highly attractive because of high atom efficiency and environmental friendliness. Notably, this research would facilitate the progress of acceptorless dehydrogenative reactions in water.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
