Abstract
ABSTRACTAim: To compare the acceptability and efficacy of orally administered commercially available midazolam syrup and injection midazolam mixed in honey for performing venepuncture.Materials and methods: This double blind randomized controlled trial enrolled 40 anxious and healthy 2 to 6 years olds. All subjects received either syrup midazolam or injection midazolam mixed in honey (0.5 mg/kg) per orally, prior to venepuncture as per their group assignment. Primary outcome measures in this trial was acceptability of midazolam. Secondary outcome measures included sedation depth, success of venepuncture, observer and parental satisfaction and parental perception of child's pain.Results: Although the acceptability of syrup midazolam (95%) was higher than injection midazolam (80%), there was no significant difference among two groups with respect to any primary or secondary outcome (p > 0.05).Conclusion: Syrup midazolam can serve as a suitable alternative to injection midazolam; thus, eliminating the procedural steps of mixing injection midazolam with any vehicle.How to cite this article: Srivastava B, Mittal N, Mittal P. Acceptability and Efficacy of Commercial Oral Preparation of Midazolam for brief Painful Procedure: A Randomized Double Blind Clinical Trial. Int J Clin Pediatr Dent 2014;7(3):153-156.
Highlights
The pediatric population seems to have undergone a qualitative transformation; being less cooperative than earlier
Results: the acceptability of syrup midazolam (95%) was higher than injection midazolam (80%), there was no significant difference among two groups with respect to any primary or secondary outcome (p > 0.05)
Syrup midazolam can serve as a suitable alternative to injection midazolam; eliminating the procedural steps of mixing injection midazolam with any vehicle
Summary
The pediatric population seems to have undergone a qualitative transformation; being less cooperative than earlier. Restraint and HOME are commonly employed measures to gain control over tantrum throwing children; but, these obviously have psychological trauma associated with them, with greater number of parents and dentists recognizing it.[3,4] The scenario becomes worse when there is an urgency to treat as in case of a painful abscessed tooth or trauma. Under such circumstances, the practitioner has to resort to pharmacotherapeutic means of behavior management. Midazolam has been extremely popular[5,6,7,8] because of availability of multiple routes, short half life (1.5-2 hours), high potency (twice as that of diazepam), rapid onset of action (10-30 minutes depending upon the route), reliable dose dependent anxiolytic effects, and low grade anterograde amnesia
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