Abstract
ABSTRACTThe aim of the study was to study the acceptability and effectiveness of two commonly used nonsteroidal anti‐inflammatory drugs (Naproxen and Sulindac) specifically in an elderly population with symptomatic osteo‐arthritis of the hip and/or knee.39 patients aged 70 years and over with degenerative arthritis of hip or knee were randomly allocated to Sulindac or Naproxen treatment groups for a treatment period of twelve weeks.There were no pretrial differences between the two randomly allocated groups. Both Naproxen and Sulindac produced improvement in patient symptoms and there was no difference in the efficacy or acceptability of the two drugs. Both drugs were well tolerated in the study population. Side effects from Naproxen tended to occur later during the trial resulting in withdrawal of three patients after a period of six weeks. Side effects from Sulindac resulted in early withdrawal of two patients only. Patients in the Naproxen group had a minor but significant (p= <.01) increase in the platelet count during the trial period while patients in the Sulindac group had significant (p □ <.001) elevation in serum alkaline phosphatase. No patient developed hepatotoxicity. The appropriateness of a primary health care setting for evaluating the efficiency and acceptability of drugs meant to alleviate symptoms in an elderly population functioning in the community is stressed.
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