Abstract
IntroductionPhysical activity (PA) may play a role in maintenance of cognitive function in both middle and older ages and prevention of outcomes such as dementia and Alzheimer's disease. MethodsCross-sectional regression analyses were performed in Framingham Heart Study Third Generation (n = 1861) and Offspring (n = 909) cohort participants assessing the association of accelerometry-measured PA with cognitive function, adjusting for age, sex, accelerometer wear time, education, occupational status/PA, and smoking status. ResultsIn each cohort, achieving just 10–21.4 min/day moderate-to-vigorous PA related to better executive function (P < .02); and just 10 min/day moderate-to-vigorous PA was associated with better verbal memory in middle-aged adults in the Third Generation cohort (P = .02). In older adults of the Offspring cohort, total PA (measured in steps/day) was associated with better executive function (P < .02). DiscussionPA at levels lower than the current PA Guidelines (just 10 min/day moderate-to-vigorous PA and total PA including lower intensity PA) were associated with better cognitive function.
Highlights
There are currently limited treatment options for dementia and Alzheimer’s disease (AD)
We evaluated models that adjusted for additional cardiovascular risk factors (BMI, diabetes mellitus (DM), HTN, and prevalent cardiovascular disease (CVD)) and assessed potential selection bias using the c2 analysis and t-tests to compare demographic details from participants who did and did not complete the physical activity (PA) accelerometry study
The Framingham Third Generation participants were younger than the Offspring participants, were more likely to have completed college education (57% vs. 47%), had higher cognitive function scores, and were less often retired or underemployed (26% vs. 76%); almost 55% of Offspring participants were retired at the time of the examination
Summary
There are currently limited treatment options for dementia and Alzheimer’s disease (AD). In the current cross-sectional investigation, we explored associations of objectively measured PA and SED with cognitive function in two different generations of the Framingham Heart Study (FHS), the older Offspring cohort and the Third Generation cohort, consisting mainly of the middle-aged children of the Offspring cohort. Leveraging these two cohorts enables investigation of precise doses of PA and SED and of the influence of age, education, and occupational PA/status on the association between PA and SED with cognitive function
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