Abstract
Background: Phytomedicines are gaining a spotlight in wound management, where much research has suggested the wound healing potential of Barringtonia racemosa. The objective of this study was to investigate the effectiveness of B. racemosa kernel extract in accelerating wound healing process in animal models. Methods:B. racemosa kernel was extracted using ethanol:water (7:3) solvent and was then used as a bioactive ingredient in a Carbopol 940-based gel formulation in four different concentrations (1, 3, 5 and 7 ppm). A 3 cm diameter wound was made in the dorsal area of Rattus norvegicus rat and wound healing process was assessed up to 12 days using DESIGN (Depth, Exudate, Size of Inflammation/Infection, Granulation tissue, and Necrotic tissue) scoring system. Results: Our data suggested that the DESIGN scores were significantly different among concentration groups after the 3 rd day onward suggesting B. racemosa extract accelerated the wound healing process. Rats treated with gel formulation containing 7 ppm of B. racemosa kernel extract had faster wound healing than that treated with topical Metcovazin. Conclusion:B. racemosa kernel extract was effective in accelerating wound healing on rats. Further study is warranted to purify the bioactive component and the action mechanism in wound healing process.
Highlights
Wounds may occur on skin because of external or internal stimuli including that of physical, chemical, electrical, or thermal
B. racemosa extract with a concentration of 7 ppm could perform better wound healing on the rat models; this condition yielded 0 DESIGN score on the 11th day
On day 11, the DESIGN scores were significantly different between 7 ppm group and positive control group (p=0.0286, Mann-Whitney test) suggesting that B. racemosa extract with a concentration of 7 ppm in gel formulation could assist better wound healing than Metcovazin
Summary
Wounds may occur on skin because of external or internal stimuli including that of physical, chemical, electrical, or thermal. The objective of this study was to investigate the effectiveness of B. racemosa kernel extract in accelerating wound healing process in animal models. Methods: B. racemosa kernel was extracted using ethanol:water (7:3) solvent and was used as a bioactive ingredient in a Carbopol 940based gel formulation in four different concentrations (1, 3, 5 and 7 ppm). Results: Our data suggested that the DESIGN scores were significantly different among concentration groups after the 3rd day onward suggesting B. racemosa extract accelerated the wound healing process. Rats treated with gel formulation containing 7 ppm of B. racemosa kernel extract had faster wound healing than that treated with topical Metcovazin. Conclusion: B. racemosa kernel extract was effective in accelerating wound healing on rats. Further study is warranted to purify the bioactive component and the action mechanism in wound healing process
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