Abstract
An acceleration of the Dakin reaction caused by addition of trifluoroacetic acid is described. The modified protocol converts aromatic aldehydes to the corresponding phenols within 4 hours at room temperature by means of hydrogen peroxide in acidic medium. This acceleration is attributed to the stability of hydrogen peroxide in an acidic medium. This modified protocol provides alternative and easy access to important phenolic precursors that have been used in the synthesis of various natural products.
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