Acceleration of Peritoneal Dialysis by Surface-Active Agents

Abstract

Peritoneal dialysis is an effective method of removing endogenous poisons, but it is a slow process. In a search for agents to accelerate dialysis across the peritoneum, a number of wetting agents were tested and used in the peritoneal fluid. Dialysis tests were run on rabbits with radioactive urea and rate constants were calculated from dialysate and blood curves. The anionic and cationic wetting agents had significant effects, while the nonionic wetting agents were much weaker. On the basis of effectiveness and gross toxicity dioctyl sodium sulfosuccinate 0.01 percent was chosen as the most promising accelerator. It was evaluated in more detail and found to accelerate the dialysis of urea to about four times the rate of controls. When tested with radioactive creatinine the acceleration was two to threefold. It was concluded that dioctyl sodium sulfosuccinate is worthy of the further work required to bring it to the stage of clinical trial. Peritoneal dialysis is an effective method of removing endogenous poisons, but it is a slow process. In a search for agents to accelerate dialysis across the peritoneum, a number of wetting agents were tested and used in the peritoneal fluid. Dialysis tests were run on rabbits with radioactive urea and rate constants were calculated from dialysate and blood curves. The anionic and cationic wetting agents had significant effects, while the nonionic wetting agents were much weaker. On the basis of effectiveness and gross toxicity dioctyl sodium sulfosuccinate 0.01 percent was chosen as the most promising accelerator. It was evaluated in more detail and found to accelerate the dialysis of urea to about four times the rate of controls. When tested with radioactive creatinine the acceleration was two to threefold. It was concluded that dioctyl sodium sulfosuccinate is worthy of the further work required to bring it to the stage of clinical trial.