Abstract
The possibility that oxidative stress caused by chemotherapy would accelerate formation of pentosidine was investigated. The pentosidine levels of erythrocyte membrane protein, plasma, and urine of pulmonary cancer in patients who had been administered cisplatin were higher than those of unadministered patients. Injection of cisplatin to SD mice resulted in a gradual increase in pentosidine levels. These results suggest that oxidative stress caused by cisplatin accelerates pentosidine formation in vivo.
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