Abstract
When dextran sulfate was added at concentrations of 0.001% or 0.01% (w/v) to cultures of 3T3-L1 fibroblasts, their spontaneous adipose conversion was accelerated. The expression of a marker enzyme (glycerophosphate dehydrogenase) peaked on day 16 but later declined due to the cytotoxicity of dextran sulfate. Heparin had similar effects on adipose conversion.
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