Abstract
Adenine nucleotide synthesis de novo was studied in rat hearts during the development of cardiac hypertrophy due to aortic constriction. After an exposure of 60 min in vivo to [1- 14C]glycine, the rates of adenine nucleotide biosynthesis were computed by relating the total radioactivity of these compounds to the mean specific activity of the intracellular precursor glycine. Myocardial adenine nucleotide synthesis de novo proved to be significantly increased between the first and the fifth day after aortic constriction, reaching a maximum at the end of the third day.
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