Accelerating the convergence to a limit cycle in 3D cardiac electromechanical simulations through a data-driven 0D emulator

Abstract

The results of numerical simulations of cardiac electromechanics are typically characterized by a long transient before reaching a periodic solution known as limit cycle. This yields a serious computational overhead, as the only clinically relevant output is associated with such limit cycle. To accelerate the convergence to the limit cycle, we propose a strategy based on a surrogate model, wherein the computationally demanding 3D components are replaced by a 0D emulator, built through an automated data-driven algorithm on the basis of pressure-volume transients of as few as three heartbeats simulated with the 3D model. The 0D emulator, consisting of a time-dependent pressure-volume relationship, can provide the 3D model with an initial guess, such that in just two heartbeats a solution is reached that is as close to the limit cycle as the one obtained after more than 20 heartbeats with the 3D model. The 0D emulator is also recommended in many-query settings (e.g. when performing sensitivity analysis, parameter estimation and uncertainty quantification), that call for the repeated solution of the model for different values of the parameters. Indeed, the construction of the emulator does not have to be repeated when the parameters of the circulation model it is coupled with vary. Finally, should the parameters of the 3D electromechanical model vary as well, we propose a parametric emulator, obtained by interpolation of emulators constructed for given values of the parameters. This paper is accompanied by a Python library implementing the proposed algorithm, open to integration with existing cardiac solvers.