Abstract
A report on the 22nd Annual International Conference on Intelligent Systems for Molecular Biology, held in Boston, Massachusetts, USA, July 11-15, 2014.
Highlights
Meeting report For the first time this year at the Intelligent Systems for Molecular Biology conference, special talks honored and celebrated the Nobel laureates of Chemistry 2013 Arieh Warshel, Martin Karplus and Michael Levitt
Biomedical studies were enhanced with more data-driven projects across multiple scales, including Encyclopedia of DNA Elements (ENCODE) and The Cancer Genome Atlas; it seems that data integration remains the bottleneck of studies rather than data generation
Next- and third-generation sequencing and single-cell sequencing The industry has witnessed the progression of sequencing to next-generation techniques and a third generation, which can potentially enhance the measurement of single-cell genomes
Summary
Meeting report For the first time this year at the Intelligent Systems for Molecular Biology conference, special talks honored and celebrated the Nobel laureates of Chemistry 2013 (computational and theoretical) Arieh Warshel, Martin Karplus and Michael Levitt. The conference provided insight into innovative computational methods, such as single-cell sequencing analyses that enable unprecedented resolution for the study of disease heterogeneity, rare cell aberrations and the microbiome. Classic de novo sequence assembly usually works for reads from a single genome; studies show that combinations of multiple genomes could improve accuracies of target genome assembly.
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