Abstract
To build hippocampal memory prosthesis for restoring memory functions, we previously developed and implemented a multi-input multi-output (MIMO) nonlinear dynamic model of the hippocampus. This model can successfully predict hippocampal output spike activities based on input spike activities, and thus be used to drive microstimulation to bypass the damaged hippocampal region. Building such a MIMO model involves estimations of a large number of model coefficients, which typically takes hundreds of hours using a single personal computer. In practice, however, due to the requirement of medical care and clinical trials, the modeling processes must be completed within 72 hours after the recording, so that models can be used to drive stimulations. To solve this problem, we utilized a parallelization strategy to divide the whole MIMO model computation involving iterative estimation and optimization into independent computing tasks that can be performed simultaneously in multiple computer nodes. Such a strategy was implemented on the high-performance computing cluster at the University of Southern California. It reduced the model estimation time to tens of hours and thus allowed us to complete the modeling process within the required time frame to further test model-driven electrical stimulation for the hippocampal memory prosthesis.
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More From: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
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