Accelerated solvent extraction combined with capillary electrophoresis as an improved methodology for simultaneous determination of residual fluoroquinolones and sulfonamides in aquatic products

Abstract

A rapid and effective accelerated solvent extraction (ASE)–capillary electrophoretic method was developed for the determination of fluoroquinolone and sulfonamide residues in aquatic products. Seven residues were extracted with acetonitrile at 80 °C under 10.3 MPa pressure in less than 25 min. The standard curves for the determination of seven residues by the capillary electrophoretic method have good linearity (r2 > 0.999). The method limits of quantification (LOQs) were 70–100 μg kg−1. Their average recoveries with three spiked levels ranged from 83% to 106%. Intra- and inter-day precision (RSD) were 2.3–4.9% and 3.1–6.5%, respectively. The method provides a rapid and simple extraction procedure with high recoveries, and has been applied for the determination of 4 fluoroquinolone and 4 sulfonamide residues in aquatic products with satisfactory results.