Abstract
MgSiO3-based biodegradable ceramics demonstrated remarkable potential for treating small-scale bone defects and temporary bone replacement. In addition, the dissolution behavior of MgSiO3 bioceramics can be tuned by doping of Ca and Zr elements at Mg and Si sites, respectively. The present study reported the influence of formation of Ca- and Zr-codoped Mg1-xCaxSi1-xZrxO3 (x = 0, 0.1, 0.2, 0.3, and 0.4) bioelectrets and electrodynamic stimulation toward improving their osteogenic response. Mg1-xCaxSi1-xZrxO3 electrets were successfully synthesized by a solid-state route. A detailed X-ray photoelectron spectroscopy (XPS) analyses revealed that the electrets produced oxygen-deficient active sites. The formation of Mg1-xCaxSi1-xZrxO3 electrets significantly increased the surface hydrophilicity. Inductively coupled plasma (ICP) analyses were used to examine the leaching behavior of Ca/Zr-codoped MgSiO3 bioceramics. In vitro cell culture analyses indicated that the osteogenesis of MG-63 cells was remarkably enhanced on the electrodynamic field-treated Mg1-xCaxSi1-xZrxO3 bioelectrets as compared to hydroxyapatite (HA). Moreover, a better osteogenic response was observed for higher concentrations of Ca (0.3 and 0.4) and Zr (0.3 and 0.4) doping in the MgSiO3 bioelectrets. Further, the mechanism of enhanced cellular functionality was revealed by the measurement of intracellular Ca2+.
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