Abstract
Publisher Summary This chapter reviews and summarizes methodological and theoretical developments of the accelerated hazards model in estimation and efficiency evaluation. The accelerated hazards models, jointly with other classes of models, give users more options in modeling survival data with censored observations. However, because of its sensitivity to the baseline hazard function and the model assumptions, careful assessment of adequacy becomes a critical issue. The accelerated hazards model has flexibility to be extended in various situations when needed. Several extensions based on this model are studied and summarized in the chapter. Similar to other hazards regression models, the accelerated hazards model can be used to analyze many data sets in practice. When actually using the accelerated hazards model as an alternative in planning clinical trials, for example, simulation studies can be conducted to compute sample size calculations.
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