Abstract
Acantholytic squamous cell carcinoma (aSCC) is a rare and distinctive histologic subtype of squamous cell carcinoma characterized by acantholysis in the cancer nests leading to a pseudoglandular appearance. We describe the case of a 28-year-old female patient with symptomatic swelling in left maxilla. Radiographically, a poorly defined, multilocular, radiolucent lesion was found in the periapical region of teeth 24 and 25. Clinical diagnosis was periapical cyst, and the patient was submitted to incisional biopsy. Histologic feature of the incisional biopsy led to the diagnosis of adenocarcinoma not otherwise specified. The patient was referred to the public oncology center, tumor resection was performed, and the diagnosis of aSCC was established after analysis of the surgical specimen. Because of the high-grade features, poor differentiation, and tumor invasion pattern, the patient died after approximately 3 months from initial diagnosis; aSCC is recognized for its aggressive nature and poor prognosis, especially when it occurs in the oral cavity.
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