Abstract
AbstractClinical signs of acanthamoeba keratitis are in early stages grey‐dirty epithelium, pseudodendritiformic epitheliopathy, perineuritis, multifocal stromal infiltrates, ring infiltrate and in later stages scleritis, iris atrophy, anterior synechiae, secondary glaucoma, mature cataract, and chorioretinitis. Our finding emphasizes that pre‐testing the in vitro susceptibility of the AK isolate with the non‐nutrient E. coli agar plate assay against the anti‐amoebic drug intended for treatment will give valuable information on whether the drug is likely to be active on the Acanthamoeba isolate in vivo. In therapy resistant cases, surgical treatment options such as corneal cryotherapy, amniotic membrane transplantation, riboflavin‐UVA cross‐linking, and penetrating keratoplasty are applied.
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