Acamprosate—an Anti-Craving Drug for Alcohol Use Disorder (AUD) Pharmacotherapy: Plasma Metabolomics Signatures are Associated With Alcohol Craving Intensity and Acamprosate Treatment Response

Abstract

Acamprosate is an anti-craving drug used for the pharmacotherapy of alcohol use disorder (AUD). However, acamprosate’s mechanism(s) of action during the treatment of AUD remains unclear, and only some patients achieve optimal therapeutic outcomes. The present study was designed to explore the differences in metabolomic profiles between patients who maintained sobriety and those who relapsed. It also sought to determine whether those differences might provide insight into the mechanisms involved in the variations in acamprosate treatment response phenotypes.