Abstract
Mg1-xZnxFe2O4 (x = 0.0, 0.2, 0.4, 0.6, 0.8) nanoparticles surrounded by amorphous SiO2 were synthesized using the wet chemical method to improve their biocompatibility and magnetization, and for application as a heating medium for hyperthermia therapy. Magnetization was at its maximum for a composition of x = 0.2; this composition was then fixed and the particle size varied between 4 and 25 nm to optimize the heating effect. Analysis by alternating-current (AC) magnetic-susceptibility measurement suggested that particles sized 18 nm generated the most heat, with the system following a Debye relaxation. In the temperature-increase measurement, the maximum amount of heat was dissipated at a particle size of 18 nm, indicating that the system generates enough heat to kill cancer cells under electromagnetic fields that are acceptable to the human body. In an in vitro experiment using human breast cancer cells, we confirmed that hyperthermia suppressed 25% of the cancer cells in 30 min using 18 nm particles.
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