Abstract
The objective of the present work was to study the predominance of abzymes in the diagnosis of Bronchial Asthma. The study was carried out using the blood serum of several groups of patients, including patients with Bronchial Asthma (n=15), allergic Rhino-conjunctivitis (polypus)(n=15), Systemic Lupus Erythématosis(n=10) and Auto-Immune Thyroiditis (n=10). Detection of IgG auto-AB against DNA was carried out by Enzyme-linked immunosorbent assay (ELISA) and the catalytic activity of antibody against DNA was determined by electrophoresis method. The results of our study revealed abundant auto-antibodies to DNA in the blood vessels of the patients with bronchial asthma and there was a direct correlation dependence (r=0.0005) between the level of auto-antibodies to DNA and the severity of the disease. Circulating auto-antibodies in blood serum possess catalytic activity of DNA which is associated with the degree of severity of asthma. Thus, autoantibody can be used as serologic markers for the diagnosis of BA and can even be suitable, according to their concentration, for determining the degree of severity of the disease.
Highlights
Rottem [1] reported that the Allergy and autoimmunity can have common mechanisms in the pathogenic pathways
The study was carried out using the blood serum of several groups of patients, including patients with Bronchial Asthma (n=15), allergic Rhino-conjunctivitis (n=15), Systemic Lupus Erythématosis (n=10), and Auto-Immune Thyroiditis) (n=10) (Global Strategy of treatments and prophylactics of the bronchial asthma, 2007)
According to the results of Enzyme-linked immunosorbent assay (ELISA) test, some IgG antibodies to NDNA were found in patients with atopic (BA) and non-Atopic Bronchial Asthma
Summary
Rottem [1] reported that the Allergy and autoimmunity can have common mechanisms in the pathogenic pathways. Asthma could be intrinsic causes as in autoimmune reaction or a genetic predisposition, there is no study that has confirmed this. The analysis of auto-antibody profiles has shown to be important in the diagnosis of some auto-immune diseases, such as anti-dsDNA and anti-Sm auto-antibodies in the systemic lupus erythematosus (SLE) [2]. Abzymes (derived from antibody and enzymes) is a monoclonal antibody with catalytic activity. They are usually artificial constructs, but are found in normal humans and patients with autoimmune diseases. We deduce that catalytic activity can find its reflection in the natural potential defence of immune system for different types of autoimmune disturbances. The objective of this study was to study the predominance of abzymes in the diagnosis of Bronchial Asthma (BA)
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