Abstract
The authors evaluated the histopathologic findings of surgically excised choroidal neovascularization (CNV) in a masked fashion and compared their results with preoperative fluorescein angiographic classification as classic or occult CNV. The patients in this study were at lease 60 years old and all had age-related macular degeneration (AMD). Fluorescein angiograms were performed not more than 14 days prior to surgery. The classic versus occult fluroescein angiographic classification was made in accordance with Macular Photocoagulation Study criteria. The membranes were histologically classified as lying between the retinal pigment epithelium (RPE) and retina (Gass type 2), lying underneath the retina (Gass type 1), or as being combined. Results showed that in 18 of 19 classic membranes, the CNV exhibited the Gass type 2 pattern, with a minor component underneath the RPE in 10 cases. There were 10 occult membranes that exhibited a Gass type 1 pattern and there were 2 remaining combined membranes. This study shows that classic CNV correlates with the Gass type 2 pattern and this type of CNV may be more common than previously suspected in AMD. Occult CNV roughly correlates to the Gass type 1 pattern.—Hans E. Grossniklaus
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