Abstract
The IL-2 receptor (IL-2R) consists of three subunits, the IL-2Rα, IL-2Rβ, and IL-2Rγ chains. The IL-2-induced proliferative signals emanate from the cytoplasmic domains of IL-2Rβ and IL-2Rγ, but the nature and function of the signaling molecules that transmit these signals are not fully understood. Here, we report that Syk protein tyrosine kinase (PTK) Is physically associated with IL-2R in peripheral blood lymphocytes. cDNA expression studies further revealed that this association is critical for the IL-2-induced activation of Syk PTK, which occurs primarily via the serine-rich region of the IL-2Rβ chain, which is essential for proliferative signal transmission. Furthermore, we provide evidence that in the hematopoietic cell line, BAF-B03, the activation of Syk PTK results in the induction of the c-myc gene, an event critical for the cell proliferation. Thus, Syk PTK may be a critical integral member of the signaling molecules engaged by the IL-2R.
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