Abstract
Chronic ITP is the most common autoimmune disorder in childhood. Splenectomy is prohibided before 5 years old and after is successfull in only 70 % of the cases With corticosteroids some chronic ITP seem to respond but long term treatment leads to undesirable side effect. Use of immunosuppressive agents is open to criticism in childhood. Y.S. Ahn has reported treatment of refractory ITP in adults with Vinblastin loaded platelets with 6 complete remissions, 3 partial remissions and 2 failures. It is demonstrated that Vinca is concentrated by the platelets. The complex is rapidly cleared and ingested by macrophages leading to their destruction. 10 children from 2½ to 15 years old were treated in our department with Vincristin loaded platelets. All had chronic ITP lasting from 1 to 12 years. Steroid had given good transitory results in 4 cases. 4 cases had been previously splenectomised with failure. There were 1 good result and 3 partial transitory remissions Among 15 adults we have 2 good results. The discrepancy between Ahn's and our results is discussed according to the total amount of vinca alcaloid incubated and the number of platelets infused.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
