Abstract
Abstracts of the Total Body PET conference 2018
Highlights
Direct dynamic Positron Emission Tomography (PET) image reconstruction allows to extract parametric images with higher signal to noise ratio
The results indicate that a spatial resolution below 1 mm can be reached for the entire field of view (FoV) as well as good quality details observed in animal imaging, indicating very promising prospects for the development of a high performance preclinical system for small animal imaging
We have established the relationship between time over threshold (TOT) and energy loss by gamma quanta in the Jagiellonian Positron Emission Tomograph (J-PET) scanner built from the plastic scintillators
Summary
Direct dynamic PET image reconstruction allows to extract parametric images with higher signal to noise ratio. The aim of this work is to develop a precise simulation model based on measured crystal data and use this powerful tool to find the limits in spatial resolution for a monolithic detector for the use in TB-PET. Monoliths combine good energy and spatial resolutions at high sensitivity, offer intrinsic DOI-capabilities and are easier to fabricate, reducing the costs This is especially important for total-body PET as a large number of detectors is required. Two benefits of long axial field-of-view (FOV) PET imaging include total-body kinetic modeling to study multi-organ interactions, and using the increased sensitivity to extend the temporal dynamic range for measuring late time-point biodistribution and pharmacokinetics. The goal of this study is to extend our method to time-offlight (TOF) PET and to evaluate its expected performance by computer simulation of the PennPET Explorer system with a range of axial fields of view (AFOV) up to 70 cm. The purpose of this scientific communication is to discuss the potential impact of whole body PET instruments for assessing cardiovascular disorders with emphasis on global quantification of atherosclerotic burden
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