Abstract
Abstracts of the 50th Workshop for Pediatric Research.
Highlights
We hypothesized that maternal propofol anaesthesia during emergency caesarean section diminished cardiac injury in preterm fetuses exposed to global severe asphyxia in utero in comparison to isoflurane anesthesia
We tested if propofol decreased the activity of pro-apoptotic caspase-3 by activating the anti-apoptotic AKT kinase family and the signal transducer and activator of transcription-3 (STAT-3)
umbilical cord occlusion (UCO) resulted in global asphyxia and cardiac arrest
Summary
Matthias Seehase1,2*, Patrick Houthuizen, Reint K Jellema, Jennifer JP Collins, Otto Bekers, Boris W Kramer. Aims Cardiac dysfunction is reported after severe perinatal asphyxia. We hypothesized that maternal propofol anaesthesia during emergency caesarean section diminished cardiac injury in preterm fetuses exposed to global severe asphyxia in utero in comparison to isoflurane anesthesia. We tested if propofol decreased the activity of pro-apoptotic caspase-3 by activating the anti-apoptotic AKT kinase family and the signal transducer and activator of transcription-3 (STAT-3)
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