Abstract
On behalf of Swiss Neurological Society together with the Swiss Society for Behavioral Neurology, we are pleased to present the Abstracts of the 113th Annual Meeting, which was held from 18–19 November 2021. Fifteen (15) abstracts were selected for oral presentations and sixty-one (61) abstracts were selected as poster presentations. We congratulate all the presenters on their research work and contribution.
Highlights
Dimethyl fumarate (DMF) and teriflunomide (TFL) are two oral drugs that reduce the relapse rate in patients with relapsing-remitting multiple sclerosis (RRMS)
Emerging evidence suggests that blood pressure variability (BPV) may contribute to cerebral small vessel disease progression and cognitive impairment beyond the deleterious effects of elevated blood pressure, but the mechanisms remain largely unknown. (1,2) This study investigates if BPV is associated with white matter (WM) microstructural integrity and the slope of cognitive decline in elderly individuals with cerebral amyloid angiopathy (CAA), a well-characterized type of SVD
We aim to explore the associations between the metabolic properties of DMF and the gut microbiome and whether distinct microbial signatures can be linked to clinical response and side-effects
Summary
Dimethyl fumarate (DMF) and teriflunomide (TFL) are two oral drugs that reduce the relapse rate in patients with relapsing-remitting multiple sclerosis (RRMS). To detect occult malignancy which determines early treatment decisions, patient outcome, and guidance of secondary prevention as a stroke etiology, we aimed to develop a multiparametric predictive clinical score for occult malignancy based on associated biomarkers. Methods: Serum S-100B levels were measured on admission (within 24 h from symptom onset) in 1749 consecutive AIS patients from the multicenter BIOSIGNAL cohort study (mean age 72.0 years, 58.3% male). Uni- and multivariable general linear models were applied to investigate associations of the CP volume with clinical, MRI and laboratory measures using age, gender, disease duration, disability status, relapse in the previous year and number of T2-weighted lesions as covariates. Methods: This cross-sectional study included 90 MS patients (63% female; age: 49.2 ± 11.2 years(y); median disease duration: 18 (10–24.5) y; median EDSS 3.0 (1.5–3.5); 83% relapsing-remitting MS) and 48 healthy controls (HC; 65% female; mean: 51.1 ± 13.1 y). Continued research is being conducted to explore relationships between MRI IB and neuropsychological testing
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