Abstracts of the 10th International Conference on Cachexia, Sarcopenia and Muscle Wasting, Rome, Italy, 8-10 December 2017 (Part 1)

doi:10.1002/jcsm.12255

Abstract

Highlights

Many studies analyse body composition changes in older adults
Reduced muscular mass and excess visceral fat in patients undergoing hematopoietic stem cell transplantation (HSCT) are associated with higher mortality, longer hospitalization, longer use of immunosuppressive drugs, graft-versus-host disease, shorter disease-free interval after the HSCT and comorbidities leading to shorter survival time
The logistic regression analysis indicated that the odds ratio, in body mass index (BMI), was 0.66 (95% confidence interval; 0.48–0.85, p < 0.01) and area under the receiver operating characteristic curve (AUC) was 0.76, suggesting that BMI might be independent predictors for muscle mass wasting

Summary

Introduction

Many studies analyse body composition changes in older adults. few studies analyse body composition in elderly people with functional measures. Our study aims to evaluate the association between height-, weight-, body surface area- (BSA), or body mass index- (BMI) adjusted muscle mass indices and physical performance in Korean hemodialysis patients. Conclusions: BIO103, a new orally available small molecule, displays both in vitro and in vivo anabolic properties, activates AKT/mTOR and AMPK which translates into improved functional performance, notably in old animals These investigations demonstrate the potential of BIO103 in improving skeletal muscle quality and warrant further studies towards its development as a drug candidate for the treatment of muscle wasting disorders. Patients with advanced cancer frequently suffer a decline in activities associated with involuntary loss of weight and muscle mass (cachexia) This has profound effects on function and quality of life. Greater engagement of health professionals with this group in exploring potential benefits of exercise is required

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Conclusion