Abstract
Abstract A new inhibitor, with specificity for the reaction of the eighth component of guinea pig complement (C′8), has been generated in vitro. This inhibitor may be detected in partially purified preparations of C′8 which have lost hemolytic reactivity after storage at 0 to 4°C under conditions of low ionic strength (0.04 M relative NaCl concentration) at pH 7.5. The C′8 inhibitor also may be detected in preparations of partially purified C′8 which have lost hemolytic reactivity after treatment with extremely low concentrations of trypsin. This inhibitor was called the C′8 analogue because it appeared to be generated from the hemolytically active species of the C′8 molecule after some minor molecular alteration which resulted in the loss of hemolytic activity without change in the sedimentation constant of the molecule (7.8 S), and with very little change in the net electrical charge of the molecule.
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