Abstract
Children are an important target group for inhalation therapy, but little is known about their intellectual and inspiratory capacities to operate dry powder inhalers (DPIs). Most studies so far have focused either on a specific DPI, or on (single) inhala- tion parameters and how these are affected by airflow resistance, which leaves many questions for the development of new devices for the pediatric population unanswered. In this study, we investigated the applicability of DPIs in children by a more systematic approach by using a test inhaler with variable airflow resistance and exchangeable mouthpiece design. The test inhaler was instrumented to record inhalation curves and equipped with fiberglass optics (sinuscope) to study the passageway for the aerosol through the mouth cavity. We examined for 103 school children (aged 4-12 years) whether they were able to use the test inhaler according to the instructions given. Nearly all (91) were able to perform one or more correct inhalations. We computed PIFs, inhaled volumes, and inhalation times from in total 256 recordings, and tested relationships with height and airflow resistance upon significance. We also noted preferences for airflow resistance and mouthpiece design, and investigated how these variables affect the inhalation maneuver. Ultimately, we aim to use the data from this study not only for prescribing the most appropriate type of currently marketed DPI to children, but particularly to design a new DPI that performs well within the range of inspiratory capacities (PIF and inhaled volume) to be expected for children.
Published Version
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