Abstract
Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015) : Jeddah, Kingdom of Saudi Arabia. 30 November - 3 December 2015.
Highlights
The Klinefelter syndrome (KS), 47, XXY karyotype, is the most common chromosome aneuploidy in men characterized by hypogonadism, infertility, and other comorbidities
In this report we found that total number of four and seven critical residues of Caspase-3 and Caspase-7 respectively play very important role in binding to Plumbagin
We found several genes related to ion channel and genes involved in neuron differentiation, so that the frequently occurring seizures may be due to loss or haploinsufficiency of one or more of these genes
Summary
The Klinefelter syndrome (KS), 47, XXY karyotype, is the most common chromosome aneuploidy in men characterized by hypogonadism, infertility, and other comorbidities. The differentially expressed proteins identified were subjected to bioinformatics pathway analysis using STRING, IPA and Metacore software to find out the putative pathways involved in development of infertility in these patients Both primary and secondary infertility are due to an impairment of sperm function which is associated to some proteomic profile alterations. Materials and methods Thirty-six albino male mice were orally treated by 50 or 100 mg/kg body weight nifedipine and ethosuximide respectively for 20 days followed by another 10 days without treatment for drug withdrawal and assayed for chromosome aberrations; epididymal sperm count, motility, abnormal shape; and the testicular expressions of biomarkers gene including steroidogenic acute regulatory protein (StAR) gene were measured. Two OPs dichlorovos (DCV) and dimethoate (DM) were explored using standard protocol
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