Abstract

Abstracts from the 11th Symposium on Experimental Rhinology and Immunology of the Nose (SERIN 2017)

Highlights

  • There are few data available regarding natural history of local allergic rhinitis (LAR)

  • Our findings reveal some molecular basis for the therapeutic benefit of MP-AzeFlu in rhinitis and potentially in chronic rhinosinusitis with nasal polyps (CRSwNP)

  • The aim of this study was to investigate if TLR2 and TLR4 signaling is involved in regulating barrier function in CRSwNP

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Summary

Introduction

There are few data available regarding natural history of local allergic rhinitis (LAR). Two major clinical phenotypes of chronic rhinosinusitis (CRS), with (CRSwNP) and without nasal polyps (CRSsNP) may show different regulation of inflammation, interplay between T cell subsets, remodelling, response to microbiome and association with predisposing comorbidities, like allergy, asthma and aspirin intolerance. Methods: The expressions of IFN-I and IFN-I receptor (IFNAR1) in sinonasal tissue from controls and patients with CRS with nasal polyp (NP) were measured using real time-PCR, ELISA, and/or immunohistochemistry. Results: We found a significant change in gene expression of the nasal epithelial cells in AR patients not having the immunotherapy compared to healthy controls.

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