ABSTRACTS (BY NUMBER)

Abstract

Tissue Engineering Part AVol. 28, No. S1 AbstractsFree AccessABSTRACTS (BY NUMBER)These are the abstracts as submitted through the website. Last minute changes, title and presenting changes are not always reflected in this file.Published Online:4 Apr 2022https://doi.org/10.1089/ten.tea.2022.29025.abstractsAboutSectionsPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail Abstract 1 ENABLING TECHNOLOGIES FOR DEVELOPMENT OF BIOARTIFICIAL ORGANSCorresponding author's email: d.stamatialis@utwente.nlIn the coming years, due to the aging of the population and the low availability of donor organs there will be urgent need for bioengineered organs to assist, mimic or replace failing patient organs.These organs could be artificial, based on novel biomaterials and designs, to assist or mimic a patient organ or bioartificial: combining biomaterials and biologics (cells and tissues) to fully replace failing patient organs. In this talk, we will discuss enabling technologies for development of bioartificial organs with specific attention to bioartificial kidney, bioartificial pancreas.References(1) “Innovations in dialysis: Innovations in dialysis membranes for improved kidney replacement therapy”, Nature Reviews Nephrology, I. Geremia, D. Stamatialis (2020), 16(10) p550.2. “Frontiers in hemodialysis: Innovations and technological advances”, C Basile, A. Davenport, S. Mitra, A. Pal, D. Stamatialis, C. Chrysochou, D. Kirmizis, Artificial organs, 45 (2021) p175.Abstract 2 TRANSLATIONAL SYSTEMS BIOLOGY OF INFLAMMATION AND WOUND HEALING: FROM DATA TO MODELS TO DIGITAL TWINSCorresponding author's email: vodovotzy@upmc.eduProperly regulated inflammation is central to homeostasis, but in adequate or overly robust inflammation can lead to disease. Like many biological processes, inflammation and its various manifestations in disease are both multi‐dimensional and multi‐compartmental. Our group has carried out studies aimed at obtaining high‐dimensional, dynamic data on the etiology and progression of various inflammatory processes and diseases in samples derived from cells, animals, and people; creating computational models based on these data as well as on key principles of immunology, as well as developing novel software tools for data aggregation and analysis; and modulating the inflammatory response in an optimal spatial, temporal, and individual‐ / disease‐specific manner. These studies center on various disease states, especially trauma/hemorrhage, infection, wound healing, and liver failure, as well as the application of computational approaches to regenerative medicine, biomarker discovery, and rational drug/device design. Our ultimate goal is to gain a translational systems perspective on the inflammatory response (1,2).Keywords:Inflammation; Mathematical modeling; Systems biology