Abstract WP422: Vitamin D deficiency and Osteoporosis in Stroke Survivors: An analysis of National Health and Nutritional Examination Survey (NHANES) 2001-2006

Abstract

INTRODUCTION: Vitamin D deficiency might be involved in the development of several diseases including hypertension, diabetes mellitus and cardiovascular disease. An inverse association between 25(OH) D levels and stroke was also emphasized in recent studies. Objective: To determine the rate of vitamin D deficiency among stroke survivors and risk of associated osteoporosis in a nationally representative population. Methods: Participants from the National Health and Nutritional Examination Survey (NHANES) from 2001 through 2006 were included. Serum 25(OH) D levels were measured using the DiaSorin RIA kit (Stillwater MN) and history of previous stroke and osteoporosis was ascertained by standard interview. Stroke survivors were then divided into 2 groups depending on serum 25(OH) D levels: <30ng/dL as vitamin D deficiency and ≥30ng/dL as normal. Comparisons of demographics and risk factors between two groups were performed using the SAS software. Multivariate analysis was performed to determine the association between vitamin D deficiency and osteoporosis in stroke survivors after adjusting for potential confounding factors. Results: There were 415 (4.0%) stroke survivors among the total 10,255 participants in NHANES. The mean age [±SD] of stroke survivors was 67.56 [±17.3] years and 211 (50.8%) were men. Mean 25(OH) D concentrations were found to be not significantly different in patients with stroke (20.35 versus 21.82ng/mL, p=0.657) although the rate of osteoporosis was significantly higher among stroke survivors (17.92% versus 6.99%, p<0.0001). Out of 415 stroke patients, vitamin D deficiency was seen in 71.0% of the patients (mean concentration of 17.3±6.4ng/dL) and was normal in 29.0% patients (mean concentration of 34.6±5.3ng/dL). The rates of osteoporosis were similar between patients with or without Vitamin D deficiency. After adjusting for potential confounders, there was no association between vitamin D deficiency and osteoporosis. Conclusion: Vitamin D deficiency and osteoporosis are highly prevalent among stroke survivors, however, there does not appear to be a relationship between the two entities.