Abstract WP41: Peri-Procedural Arterial Spin Labeling and Dynamic Susceptibility contrast Perfusion in Detection of Cerebral Blood Flow in Patients with Acute Ischemic Syndrome

Abstract

Purpose: To investigate the potential clinical value and diagnostic performance of arterial spin-labeled (ASL) and dynamic susceptibility contrast (DSC) perfusion in detection of cerebral blood flow (CBF) changes before and after endovascular recanalization in patients with acute ischemic syndrome (AIS). Methods: This retrospective study was performed using MR examinations between 2010-2012. Inclusion criteria were: patients with AIS who underwent endovascular recanalization and acquisition of both ASL and DSC before and after revascularization. ASL CBF and multiparametric DSC perfusion maps were qualitatively evaluated for image quality, presence of hypo or hyperperfusion and location of perfusion abnormality. Lesion segmentation for infarct core (ADCb >550) and hypoperfused area (TMax > 4 sec) was performed on DSC. rCBF was calculated using a regions-of-interest (ROI) method in the infarction core and hypoperfused areas using coregistered ASL and DSC images. Core and hypoperfused rCBF ROI’s were used for paired pre- and post-treatment intermodality comparisons. Interobserver and intermodality agreement was evaluated by Kappa test. T-test and Spearman correlation coefficients were calculated for ASL and DSC rCBF values. Results: Twenty-five patients were met our inclusion criteria. Five studies were rated non-diagnostic, resulting in a total of 45 pair of DSC-ASL for comparison. ASL and DSC agreed on type of perfusion abnormality in 32 of 45 cases (71%) and location of the perfusion abnormality in 36 of 45 cases (80%). The image quality of ASL was lower than DSC, resulting in interobserver variability for the type (k =0.45) and location (k=0.56) of perfusion abnormality. ASL was unable to show any type of perfusion abnormality in 11% of patients. In patients with successful recanalization, hyperperfusion (rCBF> 1) was detected in 100% on DSC and 47% on ASL. ASL showed prolonged arterial transit effects in 58% of successfully recanalized patients. Conclusion: ASL is moderately consistent with DSC for detection of cerebral blood flow changes in patients with AIS. Qualitative and quantitative differences exist between two modalities, in particular in respect to detection of hyperperfusion in successfully recanalized patients.