Abstract
Introduction: The current management of acute ischemic stroke has changed recently with the publication of randomized trials using endovascular therapy (EVT). Rationale/Hypothesis: Limited information is however available on how physicians make decisions regarding patient selection for endovascular therapy (EVT) in the real-world. Methods: We conducted an international web-based cross-sectional survey of stroke physicians and interventionalists to assess the decision to offer EVT. Part 1 of the survey used hierarchical Bayes’ disaggregate discrete choice modelling to analyze ten pairs of patient scenarios, randomly generated from ten key patient characteristics to have respondents choose which scenario was best suited for EVT in their practice. Part 2 of the survey used mixed effects logistic regression modelling to analyze 22 randomly chosen patient scenarios, again randomly generated from several key patient and hospital level characteristics. Results: 607 physicians [mean age of 44 (SD 8.5) years, 83.5% men, 53.6% neurologists, 28.7% neuro-interventionists, 13.3% neurosurgeons, 4.7% other], from 38 countries participated. Using disaggregate discrete choice analysis, the most influential characteristic in deciding about EVT was the extent of ischemic change (ASPECTS)/volume of infarct core (26-28% of the choice). Patient age, premorbid status, baseline NIHSS score, and occlusion location (13-15% each) were the other relevant characteristics. Using mixed effects logistic regression, baseline stroke severity (NIHSS> 15 vs. NIHSS 0-5, OR 6.7; 95% CI 4.8-9.5), ASPECTS (5-7 vs. 0-4, OR 9.4; 95% CI7.4-11.9) and occlusion location (distal M2 vs. ICA/M1, OR 012; 95% CI 0.08-0.17) were the most relevant characteristics in deciding about EVT. Time from stroke onset, sex, comorbidities, time of day (off hours vs. day time) were all less relevant in deciding about EVT in both analyses. Conclusion: Severity of stroke assessed clinically, and extent of brain infarction and location of thrombus assessed on imaging are the dominant characteristics that treating physicians use in the real world when deciding about EVT for patients with an acute ischemic stroke.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
