Abstract WP386: Age-Dependent Ultrasonographic Changes After Indirect Revascularization Surgery in Patients With Moyamoya Disease

Abstract

Objective: Pediatric patients with moyamoya disease (MMD) were supposed to have better neovascularization by indirect revascularization than adult patients with MMD, but the evidence was limited. The aim of this study was to assess age-dependent ultrasonographic changes after indirect revascularization in moyamoya patients. Methods: We prospectively enrolled moyamoya patients receiving indirect revascularization and ultrasonographic exams before and after surgery at 1, 3, and 6 months. The sonographic parameters included peak-systolic velocity (PSV), end-diastolic velocity (EDV), flow resistance, and flow volume (FV) in the superficial temporal artery (STA) and external carotid artery (ECA). The values and percentage changes of the sonographic parameter at the aforementioned time points were compared between pediatric and adult patients. Results: There were 47 hemispheres in pediatric and 16 hemispheres in adult patients with MMD receiving indirect revascularization. Before surgery, adult patients had higher EDV, lower resistance, and larger FV in the STA and ECA compared to pediatric patients (all p <0.05). After surgery, pediatric patients had higher PSV in the STA and ECA compared to adults, but the resistances of these 2 arteries remained higher in pediatric patients than that in adults (all p <0.05). The percentage changes of PSV in the STA at 3 and 6 months, FV in the STA at 3 months, as well as PSV and FV in the ECA at 6 months in pediatric patients were all larger than those in adult patients (all p <0.05). Conclusion: Pediatric patients with MMD had larger increase of PSV and FV in the STA and ECA after indirect revascularization than adult patients.