Abstract WP279: Cardiac Biomarkers Predict Large Vessel Occlusion in Patients With Ischemic Stroke

Abstract

Background and Purpose: Cardiac biomarkers may help identify stroke mechanisms and may aid in improving stroke prevention strategies. There is limited data on the association between these biomarkers and large vessel occlusion (LVO) in patients with acute ischemic stroke (AIS). We aim to determine the association between cardiac biomarkers [cardiac troponin and left atrial diameter (LAD)] and the presence of large vessel occlusion. Methods: Data was abstracted from a single center prospective AIS database over 18 months and included all patients with AIS with intracranial vascular imaging (CT angiogram or MR angiography). The presence of large vessel occlusion was defined as proximal LVO of the internal carotid artery terminus, middle cerebral artery (M1 or proximal M2), or basilar artery. Univariate analyses and predefined multivariable models were performed to determine the association between cardiac biomarkers [positive troponin (troponin > 0.1) and LAD on transthoracic echocardiogram] and LVO adjusting for demographic factors (age and sex), risk factors (hypertension, diabetes, hyperlipidemia, history of stroke, congestive heart failure, coronary heart disease, and smoking), and atrial fibrillation (AF). Results: We identified 1234 patients admitted with AIS; 886 patients (71.8%) had intracranial MRA or CTA. Of those with imaging available, 398 patients (44.9%) had LVO and 232 patients (26.2%) underwent thrombectomy. There was an association between positive troponin and LVO after adjusting for age and sex and other risk factors [adjusted OR 1.97 (1.29-3.00), P=0.002)] and this association persisted after including AF in the model [adjusted OR 1.90 (1.24-2.93), p=0.003]. There was an association between LAD and LVO after adjusting for age, sex, and risk factors [adjusted OR per mm 1.04 (1.01-1.06), p = 0.002] but this association was not present when AF was added to the model [adjusted OR 1.01 (0.99-1.04), p = 0.323]. Sensitivity analyses using thrombectomy as an outcome yielded similar findings. Conclusion: Cardiac biomarkers predict acute LVO in patients with ischemic stroke. Prospective studies are ongoing to confirm this association and to test whether anticoagulation reduces the risk of recurrent embolism in this patient population.